- The signs and symptoms of infection ... include loss of appetite, poor coat condition, anisocoria (uneven pupils), infections of the skin, bladder, and respiratory tract, oral disease, seizures, lymphadenopathy (swollen lymph nodes), skin lesions, fatigue, fever, weight loss, stomatitis, gingivitis, litter box avoidance, pancytopenia, recurring bacterial and viral illnesses, anemia, diarrhea and ...
Affected cats may develop various clinical signs, and there is a progressive deterioration in their health over time. FeLV-infected cats also commonly develop life-threatening anemia (low red blood cells). Other problems associated with FeLV infection include abortion, severe enteritis (intestinal inflammation), neurological (nerve) disease, and ocular (eye) disease.

- In its progressive form, FeLV infection is associated with conditions such as profound anemia, malignancies, and immunosuppression. Identification of a cat's infection status may require repeated testing over time, and several types of diagnostic tests. Treatment of infected cats depends on infection type, clinical signs, and patient status. The 2020 AAFP Feline Retrovirus Testing and Management Guidelines, published by the American Association of Feline Practitioners, are a key resource for expert consensus on prevention, diagnosis, and management of FeLV for veterinary practitioners in private practice, animal shelters, and catteries ( see Table: Summary of Clinical Management of Feline Leukemia Virus).

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